Total Synthesis and Structural Revision of (±)-Tricholomalides A and B
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چکیده
منابع مشابه
Dehydromicrosclerodermin B and Microsclerodermin J: Total Synthesis and Structural Revision
The total synthesis of dehydromicrosclerodermin B and microsclerodermin J is described. Efficient approaches to the unusual amino acids in the target molecules were developed on the basis of a Negishi coupling (for Trp-2-CO2 H) and Blaise reaction (for Pyrr). An incorrect assignment of the pyrrolidinone stereochemistry of both compounds was confirmed by synthesizing epimers of the proposed stru...
متن کاملConcise total synthesis and structural revision of (+)-pestalazine B.
A convergent synthesis of the proposed structure of (+)-pestalazine B has been achieved in 4 steps using the N-alkylation of an unprotected tryptophan diketopiperazine with a 3a-bromopyrrolidinoindoline as the key step. Although its structure was confirmed by X-ray analysis, the spectroscopic data did not match those of the natural product. The versatility of the methodology allowed the prepara...
متن کاملTotal synthesis and structural revision of the alkaloid incargranine B.
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متن کاملthe investigation of the relationship between type a and type b personalities and quality of translation
چکیده ندارد.
Total synthesis and structural revision of (+)-muironolide a.
Muironolide A is a fascinating tetrachlorinated marine polyketide isolated from the sponge of Phorbas sp. Only 90 μg had been isolated, and the structure was established by nanoscale NMR techniques. Herein we report the total synthesis of the substance with the assigned structure of muironolide A, propose a revised structure based on NMR data, and complete the enantioselective total synthesis o...
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ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 2009
ISSN: 0002-7863,1520-5126
DOI: 10.1021/ja9049433